The development of innovative powertrain technologies is crucial for car manufacturers to comply with decreasing CO2 emission limits. They face the challenge to develop products which fulfill customer requirements in terms of functionality, comfort and cost but also provide a significant CO2 efficiency improvement. 48 V-hybrids can achieve these conflicting goals due to their low vehicle-integration effort and system costs while substantially increasing powertrain efficiency. The variance of real-driving scenarios has to be considered in system development to achieve the maximum customer benefit with the chosen system design, such as installed electrical power or topology. This paper presents a comprehensive investigation of different 48 V-system designs under real-driving conditions. The influence of varying real-driving scenarios on component load collectives is analyzed for P1 and P2 topologies. Furthermore, the CO2 reduction potential and the influence of different hybrid functions such as electric driving is identified. The contribution of this paper is the identification of 48 V-system potentials under real-driving conditions and the corresponding component requirements, in order to support the development of customer-oriented 48 V-systems.